# Alden Scientific — Olink Proteomics

Contributed by Alden Scientific.

## Contents


| File                          | Size   | Description                                      |
| ----------------------------- | ------ | ------------------------------------------------ |
| `20260901_all_proteins.csv`   | 1.2 MB | Olink protein measurements, long format          |


At a glance:

- Proteins measured with the Olink platform
- 2,814 proteins across 12 collection dates, from 2024-10-09 to 2026-06-08
- 33,763 measurements, one per protein per date, with no missing values
- Every protein is present at every date except APOE, which is absent on 2024-10-09, 2025-03-10, 2025-05-15 and 2025-07-22

## Harmonization

From a scientist at Alden Scientific:

> These data have been harmonized to our reference cohorts, including the UK Biobank and other members of our program, enabling comparison of an individual's value to a reference distribution.

## `20260901_all_proteins.csv`


| Column           | Description                                                              |
| ---------------- | ------------------------------------------------------------------------ |
| `protein_name`   | Protein, identified by gene symbol (for example `A1BG`)                  |
| `providence_npx` | Harmonized NPX value (see below)                                         |
| `date_collected` | Sample collection date, `YYYY-MM-DD`                                     |


NPX (Normalized Protein eXpression) is Olink's relative quantification unit on a log2 scale: a difference of 1 NPX is roughly a twofold difference in protein level. NPX is relative, not an absolute concentration. Compare a protein with itself across dates, or against the reference distribution, rather than one protein with another.

Collection dates and the number of proteins measured on each:


| Date collected | Proteins |
| -------------- | -------- |
| 2024-10-09     | 2,813    |
| 2024-11-20     | 2,814    |
| 2024-12-11     | 2,814    |
| 2025-01-20     | 2,814    |
| 2025-03-10     | 2,813    |
| 2025-04-09     | 2,814    |
| 2025-05-15     | 2,813    |
| 2025-05-28     | 2,814    |
| 2025-07-22     | 2,813    |
| 2026-02-23     | 2,814    |
| 2026-02-24     | 2,814    |
| 2026-06-08     | 2,814    |


## Checksum

```
ec337d841e8c6b9e429694ac55232dba  20260901_all_proteins.csv
```